Logo for: Centerchem, Inc
INCI Name:
Biphenyl Azepanyl Methanone
  • BEL-EVEN® was specifically developed for skin care applications by using a rational design approach. It locally rebalances the negative, long-term effects of stress on skin and visibly reduces signs of a stressful lifestyle for fuller, more supple looking skin with improved skin elasticity and greater barrier integrity. 
  • Ex vivo
    • 11β-HSD1 is expressed in the skin epidermis and dermis and expression of 11β-HSD1 increases significantly with UV irradiation (3J/cm2)
    • BEL-EVEN® prevents from UV and Cortisol induced collagen degradation
  • In vivo
    • After 12 weeks, facial skin elasticity significantly improves by +15.7%                                      
    • Helps increase skin density significantly after 4 & 12 weeks
    • Improves barrier function as panelists move into the winter months
    • Skin appears firmer and smoother, visibly improving the appearance of wrinkles